Adobe Flash Player is required to view this feature. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Original Article Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease Marc S. Sabatine, M.D., M.P.H., Robert P.

Giugliano, M. Anytone At-588 Vhf Manual on this page. D., Anthony C. Keech, M.D., Narimon Honarpour, M.D., Ph.D., Stephen D.

Mar 17, 2017. Original Article from The New England Journal of Medicine — Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease. [EBOOK] DOWNLOAD Machine Learning: The Ultimate Beginners Guide For Neural Networks, Algorithms, Random Forests and Decision Trees Made Simple READ -. [PDF] DOWNLOAD Finding Your Element: How to Discover Your Talents and Passions and Transform Your Life ANY FORMAT - by Ken Robinson. Buy The Element: How Finding Your Passion Changes Everything by Ken Robinson, Lou Aronica (ISBN: 425) from Amazon's Book Store. Everyday low prices and free delivery on eligible orders. Statistical Techniques Statistical Mechanics.

Wiviott, M.D., Sabina A. Murphy, M.P.H., Julia F. Kuder, M.A., Huei Wang, Ph.D., Thomas Liu, Ph.D., Scott M. Wasserman, M.D., Peter S. Sever, Ph.D., F.R.C.P., and Terje R. Pedersen, M.D., for the FOURIER Steering Committee and Investigators N Engl J Med 2017; 376:1713-1722 DOI: 10.1056/NEJMoa1615664 open through May 10, 2017. Methods We conducted a randomized, double-blind, placebo-controlled trial involving 27,564 patients with atherosclerotic cardiovascular disease and LDL cholesterol levels of 70 mg per deciliter (1.8 mmol per liter) or higher who were receiving statin therapy.

Patients were randomly assigned to receive evolocumab (either 140 mg every 2 weeks or 420 mg monthly) or matching placebo as subcutaneous injections. The primary efficacy end point was the composite of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization. The key secondary efficacy end point was the composite of cardiovascular death, myocardial infarction, or stroke. The median duration of follow-up was 2.2 years. Results At 48 weeks, the least-squares mean percentage reduction in LDL cholesterol levels with evolocumab, as compared with placebo, was 59%, from a median baseline value of 92 mg per deciliter (2.4 mmol per liter) to 30 mg per deciliter (0.78 mmol per liter) (P. Figure 2 Cumulative Incidence of Cardiovascular Events.

Panel A shows the cumulative event rates for the primary efficacy end point (the composite of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization), and Panel B shows the rates for the key secondary efficacy end point (the composite of cardiovascular death, myocardial infarction, or stroke). I bars indicate 95% confidence intervals. The Kaplan–Meier rates for the primary end point in the evolocumab group versus the placebo group were as follows: at 1 year, 5.3% (95% confidence interval [CI], 4.9 to 5.7) versus 6.0% (95% CI, 5.6 to 6.4); at 2 years, 9.1% (95% CI, 8.6 to 9.6) versus 10.7% (95% CI, 10.1 to 11.2); and at 3 years, 12.6% (95% CI, 11.7 to 13.5) versus 14.6% (95% CI, 13.8 to 15.5). The Kaplan–Meier rates for the key secondary end point in the evolocumab group versus the placebo group were as follows: at 1 year, 3.1% (95% CI, 2.8 to 3.4) versus 3.7% (95% CI, 3.4 to 4.0); at 2 years, 5.5% (95% CI, 5.1 to 5.9) versus 6.8% (95% CI, 6.4 to 7.3); and at 3 years, 7.9% (95% CI, 7.2 to 8.7) versus 9.9% (95% CI, 9.2 to 10.7).